I tried every combination of graphical settings known to man, as well as different graphics cards and different computers, just to make sure it was a monitor issue and not on the computer end.

AMD is really struggling to come up with a competitive graphics card.

Fast paced games like Overwatch or Counterstrike:GO can easily run at over 200fps with a modern graphics card at 1080p, and this monitor looks amazingly smooth and has a great response time

This will run anything you throw at it linked up to a good graphics card of course

I set custom color profile and left R and G channels at 100 and drained blue to 50, still eye strain