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lack of sharpness; lack of consistency; very slow auto focus; very loud.
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The lack of VR makes it a little trickier to use as a plain walk-around lens, though.
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The only downsides are the lack of VR (but most good macro shots I make are with tripods), the focusing is slightly louder and slightly slower than the internal motors for AF-S, and it won't autofocus with the Nikon D40, D40X, D3100 and D5000.Important settings the instructions did not mention: Some new users had issues with error message "EE
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It is very easy to focus and lack of vibration reduction is not an issue
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Telephoto shots were encouraging, but not quite as sharp as I'd expected
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As good as, if not better than, the Nikon equivalent... and less than half the price.